The hotel's centrally located position, near the Termini Railway Station, makes for an easy walk to the National Museum of Rome, the Basilica of Santa Maria Maggiore, the Trevi Fountain, the Coliseum, Imperial Forums, and the Opera House and makes the hotel an ideal site for those coming to Rome by air or by train.

197 rooms are all tastefully decorated in traditional style. The Hotel Massimo D'Azeglio also offers a Restaurant and a Wine Cellar, renown in Rome.